Medical Devices Summaries
Gelberman, Richard ; Sakiyama-Elbert, Shelly ; Schwartz, Andrea "Annie" ; Silva, Matthew ; Thomopoulos, Stavros ; Xia, Younan ; Xie, Jingwei
T-010125
— Background: Despite advanced surgical techniques and improved rehabilitation therapies, outcomes of tendon repairs are still highly variable. Current surgical interventions are perhaps unsuccessful due to the relatively few numbers of cells present at the repair site. An engineered delivery of stem …
Scanning Apparatus for Reflection-Mode Photoacoustic TomographyMaslov, Konstantin ; Wang, Lihong
T-007645
— The greatest limitation on clinical use of existing photo-acoustic imaging technologies is the slow scanning speed caused by mechanical scanning, the bulky design of the scanning apparatus, and the necessity to immerse the body part into a ultrasonic coupling liquid. The present invention overcomes…
Insert device that enhances MR and PET image resolution for MR-PET machinesTai, Yuan-Chuan
T-007555
— Background PET-CT scanners have been widely used in the identification of tumors and localization for biopsies due to its superior ability to detect biochemical and physiological functions. However, one of the main limitations of PET-CT is the inability to visualize soft tissues, which may be impor…
Multi-focus optical-resolution photoacoustic microscopy with ultrasonic array detectionMaslov, Konstantin ; Rao, Bin ; Song, Liang ; Wang, Lihong
T-010922
— In clinical practice, high imaging speed is critical to reduce motion artifacts, cost, and patient discomfort. Researchers at Washington University have developed multi-focal optical-resolution photoacoustic microscopy (MFOR-PAM) capable of high-resolution imaging of hemoglobin concentration and oxy…
Planar storage phosphor dosimeter for radiation therapy dosimetryLi, Hui
T-009252
— Radiation dosimetry is a type of quality assurance for radiation therapy (RT) treatment to verify performance and dosage of the therapy to ensure accuracy and patient safety. To determine beam delivery accuracy, phantom patients (made to mimic necessary properties of the body) are used daily to cali…
Portable patient isolation and sample collection system to prevent spread of COVID-19 and other respiratory infectionsIqbal, Zahid
T-019400
— Technology Description Dr. Zahid Iqbal at Washington University in St. Louis has devised a portable, wearable patient isolation/oxygenation system designed to protect health care workers from respiratory infections (e.g., COVID-19) while facilitating diagnostic sample collection. This viral contai…
“Gemini” connector device to prevent peripheral venous catheters from dislodging and leakingArias, Eric ; Bayly, Philip ; Dacey, Ralph ; Derdeyn, Colin ; Genin, Guy ; Kim, Albert ; Leuthardt, Eric ; Norlin, James ; Scheid, Brittany ; Singamaneni, Srikanth ; Vemuri, Chandu ; Wang, Lihong ; Zipfel, Gregory
T-014841
— Technology Description A team of researchers at Washington University in St. Louis have developed the patented “Gemini” breakaway connector to turn peripheral venous catheter (PVC) fluid flow on and off without leaking. In addition, this easy-to-use device is designed to prevent PVC di…
ACALADE: surgical device designed for faster, safer lumbar discectomyJohnson, Tim ; Leuthardt, Eric ; Moran, Daniel ; Reynolds, Benton ; Stoev, Ivan ; Wright, Neill
T-016236
— Technology Description A team of researchers at Washington University have developed ACALADE (Advanced Capability Lumbar Discectomy), a device designed to help surgeons safely access and quickly remove the back portions of herniated discs for faster, lower risk lumbar discectomy. Currently, about…
Atrial fibrillation treatment with patient-specific model to design ablation lesionsDamiano, Ralph ; Schuessler, Richard
T-005819
— Technology Description This technology is a patented method aimed at increasing the success rate of atrial fibrillation (AF) treatment by designing customized, patient-specific cardiac ablation lesion sets. AF, the most common sustained cardiac arrhythmia, has traditionally been treated with a ma…
ACALADE: surgical device designed for faster, safer lumbar discectomyJohnson, Tim ; Leuthardt, Eric ; Moran, Daniel ; Reynolds, Benton ; Stoev, Ivan ; Wright, Neill
T-016236
— Technology Description A team of researchers at Washington University have developed ACALADE (Advanced Capability Lumbar Discectomy), a device designed to help surgeons safely access and quickly remove the back portions of herniated discs for faster, lower risk lumbar discectomy. Currently, about…
Low-cost, synthetic hydrogel scaffold to promote nerve growth and regenerationElbert, Donald ; Roam, Jacob
T-016599
— Technology Description Engineers led by Dr. Donald L. Elbert have developed a patented, self-assembling hydrogel microsphere scaffold system designed to improve tissue regeneration by creating cell migration pathways to repair large nerve gaps. This technology generates the migration pathways by c…
Optical Resolution Photoacoustic Imaging Device for Port-Wine StainsMaslov, Konstantin ; Rao, Bin ; Wang, Lihong
T-012585
— A photoacoustic tomography device that provides high optical absorption contrast with high lateral resolution, including very good melanin distribution images, for port wine stain birthmarks.
Planar storage phosphor dosimeter for radiation therapy dosimetryLi, Hui
T-009252
— Radiation dosimetry is a type of quality assurance for radiation therapy (RT) treatment to verify performance and dosage of the therapy to ensure accuracy and patient safety. To determine beam delivery accuracy, phantom patients (made to mimic necessary properties of the body) are used daily to cali…
Method and Apparatus for Optical Time Reversal by Ultrasonic Encoding in Biological TissueAn, Woo Jin ; Wang, Lihong
T-010123
— Background: Optical imaging through a highly scattering medium, such as biological tissue, has been stymied by the loss of optical focusing inside such a medium. Current optical imaging techniques, such as optical coherence tomography, image up to approximately one optical transport mean free path…
Hands-free, Wireless Goggles for Near-infrared fluorescence and Real-time Image-guided SurgeryAchilefu, Samuel ; Akers, Walter ; Bauer, Adam ; Culver, Joseph ; Liu, Yang
T-010825
— Background: Current cancer management faces several challenges, including high occurrence of residual tumor after resection, adverse effects from sentinel lymph node (SLN) biopsy, and use of bulky systems in surgical suites for image guidance. Technology Description: To overcome these limitations, …
MR Method for Quantification of Anisotropic DiffusionConradi, Mark ; Sukstansky, Alexander ; Yablonskiy, Dmitriy
T-003068
— Magnetic Resonance (MR) is known to allow quantitative measurements of molecular diffusion in different materials. Such materials are frequently composed of structural units. Boundaries of these units serve as restrictive barriers for diffusing molecules. In case of structurally anisotropic units,…
String Theory: Neurovascular Catheter System with 2-in-1 Variable RigidityChandrasekaran, Vinay ; Genin, Guy ; Hafez, Daniel ; Hartquist, Chase ; Leuthardt, Eric ; Lowe, Halle ; Osbun, Joshua ; Zayed, Mohamed
T-019184
— An interdisciplinary team at Washington University has developed an easy-to-use neurovascular catheter system designed to reduce surgery time and prevent herniation during transradial interventions for stroke, aneurysms and other conditions. This device, called “String Theory”, can be sw…
String Theory: Neurovascular Catheter System with 2-in-1 Variable RigidityChandrasekaran, Vinay ; Genin, Guy ; Hafez, Daniel ; Hartquist, Chase ; Leuthardt, Eric ; Lowe, Halle ; Osbun, Joshua ; Zayed, Mohamed
T-019184
— An interdisciplinary team at Washington University has developed an easy-to-use neurovascular catheter system designed to reduce surgery time and prevent herniation during transradial interventions for stroke, aneurysms and other conditions. This device, called “String Theory”, can be sw…
Low-cost optical sensors for high performance, discrete hearing aidsLiao, Jie ; Yang, Lan
T-019167
— Technology Description A team of engineers in Prof. Lan Yang’s laboratory have developed ultra-sensitive, broad bandwidth optical sensors that could detect sound in low-cost, discrete hearing devices. This technology utilizes whispering gallery mode (WGM) resonators as compact photonic vibra…
Adhesive coated sutures for stronger musculoskeletal repairsGenin, Guy ; Linderman, Stephen ; Thomopoulos, Stavros
T-014989
— Technology Description An interdisciplinary team at Washington University in St. Louis has developed patented adhesive-coated sutures with the potential to reduce ruptures following surgical repair of tendons and ligaments. These modified sutures are designed to minimize stress by shifting the mec…
Stent System for the Treatment of Aorto-Iliac Occlusive DiseaseWirtz, Alexander ; Zayed, Mohamed
T-018558
— Technology Description Researchers at Washington University in St. Louis developed an improved stent system to treat aorto-iliac occlusive disease. Aorto-iliac occlusive disease is caused by atherosclerotic plaque accumulation in the abdominal aorta where it connects to the common iliac arteries. …
Biomimetic device for stronger repair of rotator cuff and other soft tissue-to-bone tearsGalatz, Leesa ; Genin, Guy ; Hoppe, Ethan ; Smith, Lester ; Thomopoulos, Stavros ; Yoon, Dong Hwan
T-019211
— Technology Description A team of engineers led by Professor Guy Genin has developed a device to strengthen the reattachment of soft tissue to bone for use in orthopedic procedures such as rotator cuff repairs. Although tendon and ligament tears are common, the techniques used to reattach these tis…
SPARTA – A Stent for Fusiform Aneurysms that Prevents EndoleaksBayly, Philip ; Derdeyn, Colin ; Elbert, Donald ; Genin, Guy ; Leuthardt, Eric ; McCoy, Kathleen ; Suh, JunWoo ; Teh, Yuni ; Vemuri, Chandu ; Zhao, Alan ; Zipfel, Gregory
T-015969
— Background: Popliteal artery aneurysms are the most prevalent type of peripheral aneurysms and are treated surgically to prevent rupture. Currently, surgical options include open surgery or endovascular aneurysm repair (EVAR). EVAR is less invasive than open surgery, resulting in shorter hospital st…
Steerable Thermoablation Probe for Improved Access to Brain LesionsLeuthardt, Eric
T-015768
— Technology Description An interdisciplinary team led by Professor Eric Leuthardt has developed a steerable device that can be integrated into existing thermoablation systems to treat abnormal brain lesions. Thermoablation is a more targeted and less disruptive method for treating lesions than chem…
Brachytherapy device for outpatient, MRI-guided treatment of gynecological cancersGrigsby, Perry
T-012905
— Technology Description Researchers in Dr. Perry Grigsby’s lab have developed a patented brachytherapy device for outpatient, MRI-guided treatment of gynecological cancers. Gynecological cancers, such as recurrent endometrial and cervical cancers, can be treated with brachytherapy, but requir…
Applicator device for reducing artifacts in MR-guided gynecological brachytherapyGrigsby, Perry ; Zoberi, Jacqueline
T-011297
— Technology Description Radiation oncologists at Washington University in St. Louis have developed a patented plastic sheath applicator device to improve treatment planning and tumor targeting in image-guided brachytherapy (IGBT) for uterine and cervical cancer. Currently, high-dose rate brachyther…
Neural interface device for complex, specific stimulation of peripheral nervesChristiansen, Blaine ; MacEwan, Matthew ; Moran, Daniel
T-007621
— Technology Description This technology is patented bipolar sieve electrode designed to stimulate peripheral nerves in a specific direction and thereby expand the potential of using this type of neural interface device in clinical applications such as nerve regeneration and prosthetics. Sieve elec…
Barbed mesh for fast, suture-less surgical wound closureFelder, John
T-018828
— Technology Description: A surgeon at Washington University in St. Louis has designed a barbed mesh wound closure device with the potential to save time and improve outcomes by eliminating the need for surgical suturing to close incisions of the skin and fascia. This device has applications in a var…
Versatile airway management system to reduce exposure to aerosolized SARS-CoV-2 and other pathogensIqbal, Zahid ; Lee, Jin Vivian ; Zayed, Mohamed
T-019443
— Technology Description Researchers in Dr. Mohamed Zayed’s laboratory have developed a versatile, sealable valve system for airway management devices that can protect healthcare workers by reducing their risk of exposure to aerosolized SARS-CoV-2 and other pathogens during risky pulmonary pro…
Device for diabetes cell replacement therapyMillman, Jeffrey ; Song, Jiwon
T-016681
— Technology Description Researchers at Washington University in St. Louis have developed a 3D-printed device for the subcutaneous transplantation of stem cell-derived beta (SC-beta) cells for diabetes cell replacement therapy. Diabetes mellitus, a disease characterized by loss of blood glucose cont…
Optimized Non-Coplanar Radiation Delivery for Simpler, Faster, and Safer TreatmentsMutic, Sasa ; Zhang, Tiezhi
T-016307
— Existing LINACs inefficiently deliver non-coplanar beams The goal of radiation treatment is to precisely deliver a prescribed radiation dose to the targeted tissue, while avoiding dosing the surrounding normal tissues and organs. These treatments require radiation beams to be delivered from multipl…
Barbed mesh for fast, suture-less surgical wound closureFelder, John
T-018828
— Technology Description: A surgeon at Washington University in St. Louis has designed a barbed mesh wound closure device with the potential to save time and improve outcomes by eliminating the need for surgical suturing to close incisions of the skin and fascia. This device has applications in a var…
Versatile airway management system to reduce exposure to aerosolized SARS-CoV-2 and other pathogensIqbal, Zahid ; Lee, Jin Vivian ; Zayed, Mohamed
T-019443
— Technology Description Researchers in Dr. Mohamed Zayed’s laboratory have developed a versatile, sealable valve system for airway management devices that can protect healthcare workers by reducing their risk of exposure to aerosolized SARS-CoV-2 and other pathogens during risky pulmonary pro…
Device for diabetes cell replacement therapyMillman, Jeffrey ; Song, Jiwon
T-016681
— Technology Description Researchers at Washington University in St. Louis have developed a 3D-printed device for the subcutaneous transplantation of stem cell-derived beta (SC-beta) cells for diabetes cell replacement therapy. Diabetes mellitus, a disease characterized by loss of blood glucose cont…
Arteriovenous graft designed to prevent thrombosis and graft failureGenin, Guy ; Williams, Dillon ; Zayed, Mohamed
T-018994
— Technology Description Prof. Mohamed Zayed and colleagues have developed an arteriovenous graft cuff with features designed to normalize the blood shear rate and decrease risk of thrombosis at the venous end anastomosis. This device could reduce the failure rate of these grafts, thereby improving …
Neural interface device for complex, specific stimulation of peripheral nervesChristiansen, Blaine ; MacEwan, Matthew ; Moran, Daniel
T-007621
— Technology Description This technology is patented bipolar sieve electrode designed to stimulate peripheral nerves in a specific direction and thereby expand the potential of using this type of neural interface device in clinical applications such as nerve regeneration and prosthetics. Sieve elec…
3D tissue culture device that mimics cancer metastasis for in vitro drug discoveryNasrollahi, Samila ; Pathak, Amit
T-016671
— Technology Description Engineers in Prof. Amit Pathak’s laboratory have developed a 3D tissue culture device with chambers of variable, tunable stiffness to mimic the multiple microenvironments cancer cells experience in vivo as they metastasize. Traditional 3D extracellular matrix (ECM) mod…
Vascular graft to promote stem cell therapy for diabetes and other diseasesMillman, Jeffrey ; Zayed, Mohamed
T-016290
— Technology Description An interdisciplinary team at Washington University in St. Louis has developed a multi-layered arteriovenous graft device that enhances the survival and function of stem cell transplants to treat Type 1 diabetes or other diseases. Artificial organs derived from stem cells cou…
Rotoscope – A Self-Cleaning EndoscopeGenin, Guy ; Leuthardt, Eric ; Margolis, Daniel ; Somers, Thane ; Yarbrough, Chester
T-016245
— Technology Description: Drs. Eric Leuthardt and Guy Genin have devised a medical device designed for faster and safer endoscopic surgeries. During these surgeries, the camera lens of the endoscope can become obscured with blood, fog and debris. This slows down the procedure, as the surgeon has to r…
Trackable pedicle screwsBrunner, Peter ; Genin, Guy ; Hacker, Carl ; Leuthardt, Eric ; Lowe, Halle ; Molina, Camilo ; Moran, Daniel ; Repka, Alicia ; Sandler, Jacob
T-019941
— Technology Description Researchers at Washington University in St. Louis have developed a system that uses lenticular arrays to better track pedicle screw placement during spinal fusion surgery. By enabling an accurate assessment of the screws’ locations, this system allows for computer-auto…
Lightweight, wearable cap for bedside functional optical neuroimagingBergonzi, Karla ; Culver, Joseph ; Eggebrecht, Adam ; Ferradal, Silvina
T-013611
— Technology Description Researchers in Prof. Joseph Culver’s laboratory have developed a patented, compact, lightweight functional neuroimaging device for long-term bedside monitoring. This technology, based on high-density diffuse optical tomography (HD-DOT), could be used as a surrogate for …
Robust, scalable phase control system for non-invasive neuromodulation devicesLi, Jr-Shin ; Zlotnik, Anatoly
T-016206
— Technology Description: Researchers in Prof. Jr-Shin Li’s laboratory have developed a robust, scalable, patented technology to control and entrain complex, noisy, non-linear oscillating systems such as neuronal firing and circadian rhythms. This system uses a single global, open-loop control …
Self-capacitance Power Transfer for Efficient Wireless Charging of Small WearablesAlazzawi, Yarub ; Aono, Kenji ; Chakrabartty, Shantanu ; Scheller, Erica
T-018759
— Technology Description Engineers in Prof. Shantanu Chakrabartty’s laboratory have developed a convenient, wireless power transfer system that exploits the body’s self-capacitance to charge small, low power, wearable and minimally-invasive devices. Wearable devices traditionally rely o…
SIMPEL: electrode device to safely and precisely stimulate sympathetic nerves to treat asthma, hypertension and other conditionsCloonan, Paige ; Kamath, Ashwin ; Leuthardt, Eric ; MacEwan, Matthew ; Moore, Amy ; Moran, Daniel ; Qin, Yidan (Ida) ; Ray, Wilson ; Zhang, Christopher
T-017895
— Technology Description A team of researchers at Washington University have developed “SIMPEL”, a small, implanted electrode device designed to manage a variety of conditions (such as asthma, hypertension or neuropathy) by delivering current from a defined, fixed position near specific …
Rotoscope – A Self-Cleaning EndoscopeGenin, Guy ; Leuthardt, Eric ; Margolis, Daniel ; Somers, Thane ; Yarbrough, Chester
T-016245
— Technology Description: Drs. Eric Leuthardt and Guy Genin have devised a medical device designed for faster and safer endoscopic surgeries. During these surgeries, the camera lens of the endoscope can become obscured with blood, fog and debris. This slows down the procedure, as the surgeon has to r…
Vascular graft to promote stem cell therapy for diabetes and other diseasesMillman, Jeffrey ; Zayed, Mohamed
T-016290
— Technology Description An interdisciplinary team at Washington University in St. Louis has developed a multi-layered arteriovenous graft device that enhances the survival and function of stem cell transplants to treat Type 1 diabetes or other diseases. Artificial organs derived from stem cells cou…
Normothermic Extracorporal Liver Perfusion (NELP)Banan, Babak ; Chapman Sr., William ; Lin, Yiing
T-015492
— Background: In the U.S., ~15,000 adults and children are medically approved for a liver transplant and ~6,000 liver transplants are performed each year. Unfortunately, 30% of donor livers are unsuitable for transplantation while 1,500 patients per year die waiting for liver a transplant. The high de…
3D-printed patient-specific applicator for intensity modulated high-dose-rate brachytherapyMutic, Sasa ; Park, Chunjoo ; Zhang, Hao
T-017203
— Technology Description Inventors in Washington University’s Department of Radiation Oncology have developed a method and 3D-printed applicator for intensity modulated high-dose-rate brachytherapy that surpasses conventional brachytherapy efficiency. This device is tailored to the patient…
Versatile airway management system to reduce exposure to aerosolized SARS-CoV-2 and other pathogensIqbal, Zahid ; Lee, Jin Vivian ; Zayed, Mohamed
T-019443
— Technology Description Researchers in Dr. Mohamed Zayed’s laboratory have developed a versatile, sealable valve system for airway management devices that can protect healthcare workers by reducing their risk of exposure to aerosolized SARS-CoV-2 and other pathogens during risky pulmonary pro…
Versatile airway management system to reduce exposure to aerosolized SARS-CoV-2 and other pathogensIqbal, Zahid ; Lee, Jin Vivian ; Zayed, Mohamed
T-019443
— Technology Description Researchers in Dr. Mohamed Zayed’s laboratory have developed a versatile, sealable valve system for airway management devices that can protect healthcare workers by reducing their risk of exposure to aerosolized SARS-CoV-2 and other pathogens during risky pulmonary pro…
Mobile PET imaging systemLi, Ke ; Mathews, Aswin ; Tai, Yuan-Chuan ; Wen, Jie
T-014964
— Background PET scanners are valued for their ability to provide whole-body functional and anatomic information, important in the diagnoses and management of metabolic conditions. However, there is currently a need in the market for a smaller imaging system that can be used for point-of-care applica…
